Incidence and Levels of Aflatoxin M1 in Artisanal and Manufactured Cheese in Pernambuco State, Brazil.

Cheese is one of the most susceptible dairy foods to accumulating aflatoxins due to their high affinity to caseins. The consumption of cheese contaminated with high levels of aflatoxin M1 (AFM1) can be highly harmful to humans. The present work, based on high-performance liquid chromatography (HPLC), highlights the frequency and levels of AFM1 in coalho and mozzarella cheese samples (n = 28) from the main cheese-processing plants in Araripe Sertão and Agreste in the state of Pernambuco, Brazil. Of the evaluated cheeses, 14 samples were artisanal cheeses and the remaining 14 were industrial (manufactured) cheeses. All samples (100%) had detectable levels of AFM1, with concentrations ranging from 0.026 to 0.132 µg/kg. Higher levels (p < 0.05) of AFM1 were observed in artisanal mozzarella cheeses, but none of the cheese samples exceed the maximum permissible limits (MPLs) of 2.5 µg/kg established for AFM1 in cheese in Brazil and 0.25 µg/kg in the European countries by the European Union (EU). The high incidence of low levels of AFM1 found in the evaluated cheeses underscores the need for stringent control measures to prevent this mycotoxin in milk used for cheese production in the study area, with the aim of protecting public health and reducing significant economic losses for producers.

Dentofacial and skeletal pattern in African descendants from southeastern Brazil: clinical prospective study.

OBJECTIVE: The aim of this study was to evaluate characteristics of African-Brazilians young adults with excellent dental occlusion, including bimaxillary protrusion; compare them to European-American Caucasian standards, and determine whether there is sexual dimorphism in the display of this phenotype. METHODS: Lateral cephalometric radiographs were obtained from 43 African-Brazilians within military personnel (28 males and 15 females, average age 22.4 ± 3.4 years) with normal occlusion, selected from a group of 394 volunteers. Thirty-one angular and linear measurements were evaluated. Student's t-test for independent samples was used to compare results with those established by European-American standards, previously described in the literature. RESULTS: Considering the dentoalveolar pattern, seven angular and six linear measurements showed statistically significant differences (p< 0.001) when compared to Caucasian cephalometric standards. African-Brazilians' subjects showed lower cranial base angle (SNAr = 119.87 ± 5.66º) and anterior cranial base length (SN-distance = 68.63 ± 4.50 mm) (p< 0.001). The maxilla (SNA = 88.51 ± 3.23º) and the mandible (SNB = 85.06 ± 3.24º) were protruded in relation to the SN line (p< 0.001). Sexual dimorphism was significant for L1.NB (degrees) (p< 0.01), and interincisal angle (U1.L1) (p< 0.05). CONCLUSION: African-Brazilian young adults presented differences regarding dental and craniofacial characteristics, when compared to European-American norms. It can be stated that Caucasian cephalometric norms should not be applied to African-Brazilian faces.

Dentofacial and skeletal pattern in African descendants from southeastern Brazil: clinical prospective study

ABSTRACT Objective: The aim of this study was to evaluate characteristics of African-Brazilians young adults with excellent dental occlusion, including bimaxillary protrusion; compare them to European-American Caucasian standards, and determine whether there is sexual dimorphism in the display of this phenotype. Methods: Lateral cephalometric radiographs were obtained from 43 African-Brazilians within military personnel (28 males and 15 females, average age 22.4 ± 3.4 years) with normal occlusion, selected from a group of 394 volunteers. Thirty-one angular and linear measurements were evaluated. Student's t-test for independent samples was used to compare results with those established by European-American standards, previously described in the literature. Results: Considering the dentoalveolar pattern, seven angular and six linear measurements showed statistically significant differences (p< 0.001) when compared to Caucasian cephalometric standards. African-Brazilians' subjects showed lower cranial base angle (SNAr = 119.87 ± 5.66º) and anterior cranial base length (SN-distance = 68.63 ± 4.50 mm) (p< 0.001). The maxilla (SNA = 88.51 ± 3.23º) and the mandible (SNB = 85.06 ± 3.24º) were protruded in relation to the SN line (p< 0.001). Sexual dimorphism was significant for L1.NB (degrees) (p< 0.01), and interincisal angle (U1.L1) (p< 0.05). Conclusion: African-Brazilian young adults presented differences regarding dental and craniofacial characteristics, when compared to European-American norms. It can be stated that Caucasian cephalometric norms should not be applied to African-Brazilian faces.

RESUMO Objetivo: O objetivo do presente estudo foi avaliar características de jovens adultos afro-brasileiros com oclusão excelente, incluindo protrusão bimaxilar, e compará-los com os padrões caucasianos europeu-americanos, para determinar se há dimorfismo sexual na exibição desse fenótipo. Métodos: Radiografias cefalométricas laterais foram obtidas de 43 afro-brasileiros militares (28 homens e 15 mulheres, idade média de 22,4 ± 3,4 anos) com oclusão normal, selecionados de um grupo de 394 voluntários. Foram avaliadas 31 medidas angulares e lineares. O teste t de Student para amostras independentes foi utilizado para comparar os resultados com os estabelecidos pelos padrões caucasianos europeu-americanos, descrito previamente na literatura. Resultados: Considerando o padrão dentoalveolar, sete medidas angulares e seis lineares apresentaram diferenças estatisticamente significativas (p< 0,001) quando comparadas aos padrões cefalométricos caucasianos. Sujeitos afro-brasileiros apresentaram menor ângulo da base do crânio (SNAr = 119,87 ± 5,66º) e comprimento da base craniana anterior (distância SN = 68,63 ± 4,50 mm) (p< 0,001). A maxila (SNA = 88,51 ± 3,23º) e a mandíbula (SNB = 85,06 ± 3,24º) estavam protruídas em relação à linha SN (p< 0,001). O dimorfismo de sexo foi significativo para L1.NB (graus) (p< 0,01) e ângulo interincisal (U1.L1) (p< 0,05). Conclusão: Jovens adultos afro-brasileiros apresentaram diferenças em relação às características dentárias e craniofaciais, quando comparados às normas europeias-americanas. Pode-se afirmar que as normas cefalométricas caucasianas não devem ser aplicadas às faces de indivíduos afro-brasileiros.

Cephalometric profile norms for southeastern african-brazilian adults according to the Legan-Burstone analysis: a pilot study

The aim of this pilot study was to determine cephalometric profile norms for a sample of African-Brazilian young adults with excellent occlusion and compare them to Caucasian standards. Methods: Lateral cephalograms of 43 individuals of both genders (28 male and 15 female), with average age of 22.40 ± 3.40 years, were used to evaluate 13 variables proposed by the Legan-Burstone analysis. Student´s independent t-test was used to compare resulting values with those set by European-American standards. Results: Significant differences were found (p < 0.001) between African-Brazilians and Caucasians as for: maxillary and mandibular prognathism, vertical height ratio, lower face-throat angle, lower vertical height-depth ratio, nasolabial angle, upper and lower lip protrusion, mentolabial sulcus and vertical lip-chin ratio. Facial convexity angle, maxillary incisor exposure and interlabial gap did not present statistical differences when ethnic groups were compared. Males displayed increased lower face-throat angles and vertical lip-chin ratios (p <0.05) while females presented increased maxillary incisor exposures (p <0.05). Conclusion: Caucasian cephalometric norms do not apply to African-Brazilian young adults. Therefore, morphological differences in the faces of such individuals should be taken into account during diagnosis and orthodontic treatment planning stages.

Objetivo: O objetivo deste estudo piloto foi determinar as normas do perfil cefalométrico para uma amostra de jovens adultos afro-brasileiros com oclusão excelente e, compará-las com os padrões caucasianos. Métodos: Cefalogramas laterais de 43 indivíduos de ambos os sexos (28 homens e 15 mulheres), com idade média de 22,40 ± 3,40 anos, foram utilizados para avaliar 13 variáveis propostas pela análise de Legan-Burstone. O teste t independente de Student foi utilizado para comparar os valores resultantes com os estabelecidos pelos padrões euroamericanos. Resultados: Foram encontradas diferenças significativas (p <0,001) entre afro-brasileiros e caucasianos quanto a: prognatismo maxilar e mandibular, razão vertical da altura, menor ângulo face-pescoço, menor razão vertical altura profundidade, ângulo nasolabial, protrusão labial superior e inferior, sulco mentolabial e razão vertical lábio-mento. O ângulo de convexidade facial, a exposição dos incisivos superiores e o gap interlabial não apresentaram diferenças estatísticas quando comparados os grupos étnicos. Os homens apresentaram maiores ângulos face-pescoço e razões verticais lábio-queixo (p<0,05), enquanto as mulheres apresentaram maior exposição dos incisivos superiores (p <0,05). Conclusão: As normas cefalométricas caucasianas não se aplicam a jovens adultos afro-brasileiros. Portanto, diferenças morfológicas nas faces desses indivíduos devem ser levadas em consideração durante as etapas de diagnóstico e planejamento do tratamento ortodôntico.

Cystic partially differentiated nephroblastoma: a rare pediatric renal tumor-case report.

Cystic partially differentiated nephroblastoma is a rare renal tumor of childhood. It is part of a spectrum of multicystic renal tumors that also includes cystic nephroma and cystic Wilms' tumor. We present a case of cystic partially differentiated nephroblastoma, highlighting the clinical and imaging diagnostic challenge. Although the histological diagnostic criteria for all these 3 entities are well established, they are clinically and radiologically indistinguishable. Cystic partially differentiated nephroblastoma is often observed in male children under 2 years old. Typical clinical presentations include abdominal masses, abdominal pain and/or hematuria. Patients should be treated according to tumor histology and stage.

Association of calcified carotid artery plaque in panoramic images and diagonal earlobe crease.

OBJECTIVES:: Brazilians who are free of traditional atherogenic risk factors frequently suffer myocardial infarctions (MI). Calcified carotid artery plaque (CCAP) on panoramic images (PIs) has been shown to be a validated "risk indicator" of future MIs. The diagonal earlobe crease (DELC) is likewise a validated "risk indicator" of future MI. We sought to determine the prevalence of DELC+ among patients having CCAP+ on their PIs. METHODS:: In a masked cross-sectional study, three dentists evaluated PIs of patients (N = 481) over age 55 for presence of CCAP+. Among the CCAP+ cohort, the presence of DELC+ was determined by two additional dentists masked to the presence of CCAP+ on PIs. A control group (CCAP-) comprised of individuals with PIs devoid of plaque was similarly evaluated for evidence of DELC+. RESULTS:: A mixed-gender group (8.6%) of patients (N = 41; mean age 67.5 ± 6.8) evidenced CCAP+ on their PIs and approximately 88% of these individuals (N = 36) had concomitant DELC+. Among members of the control group (N = 41), 17 patients were DELC+. Our results demonstrated that among the full mixed-gender cohort (N = 82), the association between CCAP+ and DELC+ was statistically significant (p = 0.0001). However, when adjusting for gender, only the CCAP+ men were significantly (p = 0.00011) more likely to evidence DELC+ on clinical examination. CONCLUSIONS:: Males with atherosclerosis of their carotid arteries as evidenced by PIs displaying calcified atheromas are significantly more likely to evidence a DELC+ than those without an imaged atheroma.

Experiência Subjetiva com Medicamentos de Pacientes convivendo com o Câncer de Mama: um Fotovoz / Subjective Experience with Medications of Patients living with Breast Cancer: a Photovoice / Experiencia subjetiva con Medicamentos de Pacientes conviviendo con el cáncer de Mama: un Fotovoz

Introdução: A experiência subjetiva com medicamentos deve ser compreendida e explorada no dia a dia da prática clínica. Objetivo: Compreender a experiência subjetiva com medicamentos de mulheres convivendo com o câncer de mama. Método: Estudo qualitativo com orientação teórico-metodológica da Experiência Subjetiva com Medicamentos, proposta por Ramalho de Oliveira & Shoemaker, e do fotovoz na perspectiva de Wang & Burris, de um hospital oncológico em Minas Gerais, entre agosto e novembro de 2017. A amostra com três participantes foi estabelecida no momento em que a inclusão de novos participantes não acrescentava nada de novo à pesquisa e os objetivos foram alcançados. O critério de inclusão foi intencional entre mulheres acompanhadas pelo serviço de Gerenciamento da Terapia Medicamentosa e que aceitaram participar da pesquisa. As participantes utilizaram fotografias para retratar as suas experiências com o uso de medicamentos. Essas fotografias foram discutidas e interpretadas nos fotodiálogos, que foram gravados e transcritos, e cujos dados foram interpretados pela análise indutiva dos dados. Resultados: A experiência com o uso de medicamentos foi definida em quatro unidades temáticas: 1. Quimioterapia e a ideia de perda de cabelo; 2. Implicações da experiência subjetiva com medicamentos nas relações familiares e de trabalho; 3. Valorizando o uso da terapia endócrina: adesão ao tratamento. 4. Resposta do corpo às reações da quimioterapia! Conclusão: Os temas do estudo validaram a importância da atenção farmacêutica operacionalizada pelo gerenciamento da terapia medicamentosa no contexto da mulher com câncer de mama.

AbstractIntroduction: The subjective experience with medication must be understood and explored in the day-to-day clinical practice. Objective:To understand the subjective experience with the medications of women living with breast cancer. Method: Qualitative study with the theoretical and methodological orientation of the Subjective Experience with Medications proposed by Ramalho de Oliveira & Shoemaker and Photovoice from the perspective of Wang and Burris from a cancer hospital in Minas Gerais between August and November 2017. The sample of three participants was established at the time when the inclusion of new participants did not add anything new to the research and the objectives were achieved. The inclusion criterion was intentional among women accompanied by the Medication Therapy Management services and who accepted to participate in the study. Participants used photographs to portray their experiences with the use of medications. These photographs were discussed and interpreted in photodialogue; these were recorded and transcribed whose data were interpreted by the inductive data analysis. Results: The experience with the use of medications was defined in four thematic units: 1. Chemotherapy and the idea of hair loss; 2. Implications of subjective experience with medications in family and work relationships; 3. Valuing the use of endocrine therapy: adherence to treatment. 4. The body's response to chemotherapy reactions! Conclusion: The themes of the study validated the importance of Pharmaceutical Care operationalized by the Medication Therapy Management in the context of women with breast cancer.

Introducción: la experiencia subjetiva con medicamentos debe ser comprendida y explotada en el día a día de la práctica clínica. Objetivo: comprender la experiencia subjetiva con medicamentos de mujeres conviviendo con el cáncer de mama. Método: estudio cualitativo, con orientación teórico-metodológica de la experiencia subjetiva con Medicamentos propuesta por ramalho de oliveira & shoemaker y del Fotovoz en la perspectiva de Wang y Burris de un hospital oncológico en Minas Gerais entre agosto y noviembre de 2017. la muestra de tres participantes se estableció en el momento en que la inclusión de nuevos participantes no añadía nada nuevo a la investigación y los objetivos se alcanzaron. el criterio de inclusión fue intencional entre mujeres acompañadas por el servicio de Gestión de la terapia Medicamentosa y que aceptaron participar en la investigación. las participantes utilizaron fotografías para retratar sus experiencias con el uso de medicamentos. estas fotografías fueron discutidas e interpretadas en los fotodiálogos; estos fueron grabados y transcritos cuyos datos fueron interpretados por el análisis inductivo de los datos. Resultados: la experiencia con el uso de medicamentos fue definida en cuatro unidades temáticas: 1. Quimioterapia y la idea de pérdida de cabello; 2. implicaciones de la experiencia subjetiva con medicamentos en las relaciones familiares y de trabajo; 3. Valorizando el uso de la terapia endocrina: adhesión al tratamiento. 4. respuesta del cuerpo a las reacciones de la quimioterapia! Conclusión: los temas del estudio validaron la importancia de la atención Farmacéutica operacionalizada por la Gestión Gestión integral de la Farmacoterapia en el contexto de la mujer con cáncer de mama.

Evaluation of primary prophylaxis with propranolol and elastic band ligation in variceal bleeding in cirrhotic children and adolescents / Avaliação da profilaxia primária em crianças e adolescentes cirróticos com propranolol e ligadura elástica

ABSTRACT Background The efficacy of nonselective β-blocker and endoscopic procedures, such as endoscopic variceal ligation, as primary prophylaxis of variceal hemorrhage in cirrhotic adults was demonstrated by numerous controlled trials, but in pediatric population, few are the number of studies. Objective The objective of this study is to evaluate the primary prophylaxis with β-blocker in cirrhotic children and adolescents with portal hypertension. Methods This is a cohort study encompassing 26 cirrhotic patients. β-blocker prophylaxis was performed with propranolol. When contraindicated the use of β-blocker, or if side effects presents, the patients were referred to endoscopic therapy with band ligation. Patients were evaluated by endoscopy, and those who had varicose veins of medium and large caliber or reddish spots, regardless of the caliber of varices, received primary prophylaxis. Results Of the 26 patients evaluated, 9 (34.6%) had contraindications to the use of propranolol and were referred for endoscopic prophylaxis. Six (35.3%) of the 17 patients who received β-blocker (propranolol), had bled after a median follow-up time of 1.9 years. β-blockage dosage varied from 1 mg/kg/day to 3.1 mg/kg/day and seven (41.2%) patients had the propranolol suspended due to fail of the β-blockage or adverse effects, such as drowsiness, bronchospasm and hypotension. Patients who received endoscopic prophylaxis (elastic bandage) had no bleeding during the follow-up period. Conclusion All of the patients that had upper gastroinstestinal bleeding in this study were under propranolol prophylaxis. The use of propranolol showed a high number of contraindications and side effects, requiring referral to endoscopic prophylaxis. The endoscopic prophylaxis was effective in reducing episodes of bleeding.

RESUMO Contexto A eficácia dos beta-bloqueadores e de procedimentos endoscópicos como a ligadura elástica endoscópica para profilaxia primária de ruptura de varizes de esôfago em adultos cirróticos já foram demonstrados por inúmeros ensaios clínicos na população adulta, porém poucos são os estudos envolvendo a faixa etária pediátrica. Objetivo Avaliar a profilaxia primária com β-bloqueador em crianças e adolescentes cirróticos com hipertensão porta. Métodos Estudo de coorte envolvendo 26 pacientes cirróticos. O propranolol foi o β-bloqueador utilizado para a profilaxia. Quando contraindicado o uso de β-bloqueador, ou se efeitos colaterais presentes, os pacientes eram encaminhados para profilaxia endoscópica com ligadura elástica. Os pacientes foram avaliados por endoscopia, e naqueles que foram observadas varizes de médio e/ou grosso calibre ou presença de manchas avermelhadas nas varizes, independentemente do calibre das varizes, a profilaxia primária foi indicada. Resultados Dos 26 pacientes avaliados, 9 (34,6%) tinham contraindicações para o uso de propranolol e foram encaminhados para a profilaxia endoscópica. Seis (35,3%) dos 17 pacientes que receberam β-bloqueador (propranolol) apresentaram sangramento após mediana de tempo de acompanhamento de 1,9 anos. A dose de β-bloqueio variou de 1 mg/kg/dia a 3,1mg/kg/dia e em sete (41,2%) pacientes o propranolol foi suspenso por falha em atingir β-bloqueio ou presença de efeitos adversos, tais como sonolência, broncoespasmo e hipotensão. No grupo de pacientes que receberam a profilaxia endoscópica (ligadura elástica) não foi observado nenhum episódio de hemorragia digestiva alta durante o período de acompanhamento. Conclusão Todos os pacientes que apresentaram hemorragia digestiva alta no presente estudo estavam recebendo profilaxia com propranolol. Foi observado, ainda, elevado número de contraindicações e efeitos colaterais, com consequente encaminhamento para profilaxia endoscópica. A profilaxia endoscópica foi eficaz na redução de episódios de hemorragia digestiva alta.

EVALUATION OF PRIMARY PROPHYLAXIS WITH PROPRANOLOL AND ELASTIC BAND LIGATION IN VARICEAL BLEEDING IN CIRRHOTIC CHILDREN AND ADOLESCENTS.

BACKGROUND: The efficacy of nonselective ß-blocker and endoscopic procedures, such as endoscopic variceal ligation, as primary prophylaxis of variceal hemorrhage in cirrhotic adults was demonstrated by numerous controlled trials, but in pediatric population, few are the number of studies. OBJECTIVE: The objective of this study is to evaluate the primary prophylaxis with ß-blocker in cirrhotic children and adolescents with portal hypertension. METHODS: This is a cohort study encompassing 26 cirrhotic patients. ß-blocker prophylaxis was performed with propranolol. When contraindicated the use of ß-blocker, or if side effects presents, the patients were referred to endoscopic therapy with band ligation. Patients were evaluated by endoscopy, and those who had varicose veins of medium and large caliber or reddish spots, regardless of the caliber of varices, received primary prophylaxis. RESULTS: Of the 26 patients evaluated, 9 (34.6%) had contraindications to the use of propranolol and were referred for endoscopic prophylaxis. Six (35.3%) of the 17 patients who received ß-blocker (propranolol), had bled after a median follow-up time of 1.9 years. ß-blockage dosage varied from 1 mg/kg/day to 3.1 mg/kg/day and seven (41.2%) patients had the propranolol suspended due to fail of the ß-blockage or adverse effects, such as drowsiness, bronchospasm and hypotension. Patients who received endoscopic prophylaxis (elastic bandage) had no bleeding during the follow-up period. CONCLUSION: All of the patients that had upper gastroinstestinal bleeding in this study were under propranolol prophylaxis. The use of propranolol showed a high number of contraindications and side effects, requiring referral to endoscopic prophylaxis. The endoscopic prophylaxis was effective in reducing episodes of bleeding.

Bone density: comparative evaluation of Hounsfield units in multislice and cone-beam computed tomography

The aim of this study was to evaluate the validity of the bone density value of potential implant sites in HU obtained by a specific cone-beam computed tomography (CBCT) device. In this study, the HU values obtained using a MSCT scanner were used as the gold standard. Twenty mandibles (40 potential implant sites) were scanned using an MSCT scanner (Somatom Sensation 40) and a CBCT scanner (i-CAT). The MSCT images were evaluated using the Syngo CT Workplace software and the CBCT images, using the XoranCat software. The images were evaluated twice by three oral radiologists, at 60 day intervals. The trabecular bone density of the same area was evaluated on both images. Intraclass coefficients (ICC) were calculated to examine the agreement between the examiners and between the two periods of evaluation. The bone density and area of the ROI were compared by the Student t test and Bland-Altman analysis. ICCs were excellent. The mean HU value obtained using CBCT (418.06) was higher than that obtained using MSCT (313.13), with a statistically significant difference (p < 0.0001). In addition, Bland-Altman analysis showed that the HU measures were not equivalent. In conclusion, the bone density in HU with CBCT images obtained using the device studied proved unreliable, since it was higher than that obtained using MSCT.

Bone density: comparative evaluation of Hounsfield units in multislice and cone-beam computed tomography.

The aim of this study was to evaluate the validity of the bone density value of potential implant sites in HU obtained by a specific cone-beam computed tomography (CBCT) device. In this study, the HU values obtained using a MSCT scanner were used as the gold standard. Twenty mandibles (40 potential implant sites) were scanned using an MSCT scanner (Somatom Sensation 40) and a CBCT scanner (i-CAT). The MSCT images were evaluated using the Syngo CT Workplace software and the CBCT images, using the XoranCat software. The images were evaluated twice by three oral radiologists, at 60 day intervals. The trabecular bone density of the same area was evaluated on both images. Intraclass coefficients (ICC) were calculated to examine the agreement between the examiners and between the two periods of evaluation. The bone density and area of the ROI were compared by the Student t test and Bland-Altman analysis. ICCs were excellent. The mean HU value obtained using CBCT (418.06) was higher than that obtained using MSCT (313.13), with a statistically significant difference (p < 0.0001). In addition, Bland-Altman analysis showed that the HU measures were not equivalent. In conclusion, the bone density in HU with CBCT images obtained using the device studied proved unreliable, since it was higher than that obtained using MSCT.

Intervenção no acompanhamento dos paciente hipertensos residentes no território da Estratégia Saúde da Família São Pedro 2 em Governador Valadares - MG

A cidade mineira de Governador Valadares possui 41 Equipes de Estratégia Saúde da Família (ESF) e dentre elas a ESF São Pedro 2 se localiza em um bairro no qual a clientela adscrita é composta por uma proporção considerável de idosos, sendo assim, doenças crônicas como a hipertensão arterial sistêmica (HAS) é de alta prevalência necessitando de acompanhamento adequado. A HAS tem uma alta prevalência no Brasil e suas complicações são de grande impacto na saúde pública. É uma doença que pode e deve ser controlada, e é alvo de grande atenção em todo o sistema de saúde, mas principalmente na atenção primária à saúde, sendo desafio constante para os profissionais que trabalham nas unidades básicas de saúde. Portanto, este presente estudo, por meio da realização do diagnóstico situacional e da aplicação da metodologia do planejamento estratégico em saúde, objetivou demonstrar a necessidade e a importância da utilização do Caderno de Atenção Básica do Ministério da Saúde, como protocolo, na ESF São Pedro 2, através da criação de uma agenda específica, estratificação de risco cardiovascular, manutenção de consultas médicas e realização de exames laboratoriais oportunamente.